PLGA-PEG-PLGA
PolyVation developed process capabilities and a full set of validated analytical methods for the making and characterization of bioresorbable PLGA-PEG-PLGA block copolymers for injectable gel drug delivery formulations.
A PLGA-PEG-PLGA with block molecular weigths of 1400-1500-1400 g/mole and L/G ratio of 50/50 can be made available of the shelf in R&D and GMP grade in kg quantities.
These amphiphilic thermoresponsible triblock copolymers dissolve in water at low temperature by forming flower-like micelles. Upon injection, at body temperature the micellar solution turns into a hydrogel. The concept is sketched in the picture below. This easy to formulate and handle system offers great opportunities for innovating drug products into controlled release formulations with release periods in the range of days to weeks. Amongst other, this type of formulations could be ideal to treat post-operative pain using non-opioids, such as bupivacaine, meloxicam and funapide.
We can fully customize PLGA-PEG-PLGA triblock copolymers to your requirements.
